Larry Norton, M.D., Breast Cancer

Dr. Norton is the deputy physician in chief for breast cancer programs at Memorial Sloan-Kettering Cancer Center in New York. He is also the medical director of MSKCC's Breast and Imaging Center.
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Why LHJ loves him: We met Dr. Norton, one of the world's most distinguished experts on breast cancer, many years ago at an Institute of Medicine conference on mammography. We had a fascinating conversation then, and every encounter since has been illuminating, too.

Medical degree: Columbia University College of Physicians and Surgeons, 1972.

Postdoctoral training: Internal medicine, Bronx Municipal Hospital Center, Albert Einstein College of Medicine, Bronx, New York; medical oncology, National Cancer Institute, clinical oncology program, division of cancer treatment, Bethesda, Maryland.

Bio: Dr. Norton is also the founding incumbent of the Norna S. Sarofim Chair of Clinical Oncology at MSKCC and a professor of medicine at Weill Medical College of Cornell University. He has dedicated his life to the eradication of cancer by activities in medical care, laboratory and clinical research, advocacy, and government. He was a U.S. presidential appointee to the National Cancer Advisory Board -- the board of directors of the NCI -- serving as chair of the budget sub-committee. A former director of the American Society of Clinical Oncology, he served as president of ASCO and subsequently chair of the ASCO Foundation. He has been vice-chair of the Lymphoma Committee and a long-serving chair of the breast committee of the Cancer and Leukemia Group B. Dr. Norton is a founder of the Breast Cancer Research Foundation and is currently its scientific director. He has served on or chaired numerous committees of the National Cancer Institute, National Institutes of Health, and the Institute of Medicine of the National Academy of Sciences. He is an editorial board member or reviewer for numerous medical journals and on the advisory boards of many advocacy and medical institutions including the Cold Spring Harbor Laboratory Cancer Center and several specialized programs of research excellence.

Dr. Norton's personal research has focused on the use of medicines to treat cancer, particularly the application of mathematical methods to optimizing dose and schedule. He has been involved in the development of several effective agents including paclitaxel and trastuzumab. He co-invented the Norton-Simon model of cancer growth, which has broadly influenced cancer therapy, and more recently the self-seeding concept of cancer metastasis and growth. He is the principal investigator of an NCI program project grant in models of human breast cancer and an author of more than 350 published articles and many book chapters.

For his work Dr. Norton has received many honors, including election to Phi Beta Kappa and Alpha Omega Alpha and recognition from the M.D. Anderson Cancer Center, the Society for MSKCC, the Italian-American Foundation for Cancer Research, the Don Shula Foundation, SHARE (NY), the Susan G. Komen Foundation, and the Breast Cancer Research Foundation. He received ASCO's highest honor, the David A. Karnofsky Award, and was a McGuire lecturer at the San Antonio Breast Cancer Symposium. He has served as a visiting professor throughout the U.S., Canada, South America, Europe, Israel, and Asia and has trained many cancer physicians and researchers.


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