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It relieved a bee sting in minutes and reduced pain for more than five hours, according to one informal test -- better than eight other over-the-counter products and home remedies, including every sting cream and stick tried . Toothpaste's other "off-label" use? Zit zapping. Put a tiny dot on a pimple before bed. The pimple should be dried out and less noticeable by the next morning. But use only in emergencies. Toothpaste's fluoride can make acne worse, says Adam S. Stibich, MD, director of the Dermatology Clinic in Hot Springs, Arkansas.