1. Combine masa harina and chili powder in a large bowl. Add beef and toss to coat. Heat oil in a large Dutch oven over medium heat. Add 1/3 of the beef and cook until browned on all sides, about 6 minutes. Transfer to another bowl. Repeat process with remaining beef.
2. Add all the beef to Dutch oven and stir in remaining ingredients. Reduce heat to low and cook, covered, until meat is extremely tender, 3 to 4 hours, stirring often. Makes 10 cups.